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Traumatic Brain Injuries, also known as TBI,
can devastate a persons life in more ways than one. Often
resulting in permanent neurological deficits, TBIs can also lead
to changes in brain chemistry and hormone metabolism.
Because of the unique and delicate structure of the
Hypothalamic-Pituitary axis, communication pathways between
these two critics areas of the brain can result in disruption of
hormone feedback mechanisms, thus changing a persons hormones
balance. The overall health of a person relies heavily on the
neuroendocrine systems. Disrupted feedback loops can result in
problems with thyroid, stress, and sex hormones.
1-Prevalence of Neuroendocrine Dysfunction in
Patients Recovering from Traumatic Brain Injury
Steven A. Lieberman, Asra L. Oberoi, Charles R.
Gilkison, Brent E. Masel and Randall J. Urban
The Journal of Clinical Endocrinology &
Metabolism Vol. 86, No. 6 2752-2756
2-The Neuroendocrine Effects of Traumatic
Brain Injury
Micol S. Rothman, M.D., David B. Arciniegas,
M.D., Christopher M. Filley, M.D. and Margaret E. Wierman, M.D
J Neuropsychiatry Clin Neurosci 19:363-372,
November 2007
doi: 10.1176/appi.neuropsych.19.4.363
3-Neuroendocrine dysfunction in the acute
phase of traumatic brain injury.
: Clin
Endocrinol (Oxf). 2004 May;60(5):584-91.
PMID: 15104561
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